Application of Cationic Conjugated Polymer–Outer Membrane Vesicle Complexes in Inhibiting Red Blood Cell Aggregation

Hemodynamic effects of red blood cell aggregation.

The influence of red blood cell (RBC) aggregation on blood flow in vivo has been under debate since early 1900's, yet a full understanding has still has not been reached. Enhanced RBC aggregation is well known to increase blood viscosity measured in rotational viscometers. However, it has been demonstrated that RBC aggregation may decrease flow resistance in cylindrical tubes, due to the format...

Phosphorylation of the Red Blood Cell Membrane

The phosphorylation of red blood cell membrane fragments (RBCMF) during Ca ++ transport was investigated. When red cell membrane fragments are incubated with [y-a2P]ATP under the experimental condition which minimizes the phosphorylation of Na+-K+-ATPase, RBCMF are labeled in the presence of Mg ++ without Ca ++. When Ca ++ is added, the labeling decreases due to dephosphorylation of RBCMF. The ...

Thermoelasticity of red blood cell membrane.

The elastic properties of the human red blood cell membrane have been measured as functions of temperature. The area compressibility modulus and the elastic shear modulus, which together characterize the surface elastic behavior of the membrane, have been measured over the temperature range of 2-50 degrees C with micropipette aspiration of flaccid and osmotically swollen red cells. In addition,...

Vesicle tethering complexes in membrane traffic.

Despite the recent progress in the field of membrane traffic, the question of how the specificity of membrane fusion is achieved has yet to be resolved. It has become apparent that the SNARE proteins, although central to the process of fusion, are often not the first point of contact between a vesicle and its target. Instead, a poorly understood tethering process physically links the two before...

Red Blood Cell Membrane Disorder Panel